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The decrease is driven by the completion of our CoDIFy Phase 2 clinical trial of ridinilazole. Research and development expenses increased by 2.3 million to 14.2 million for the nine months ended 31 October 2016 from 11.9 million for the nine months ended 31 October 2015. This increase reflected an overall increase in investment in the DMD programme and an increase in research and development related staffing costs driven by an increase in research and development related headcount. General and Administration Expenses General and administration expenses increased by 0.6 million to 1.9 million for the three next page months ended 31 October 2016 from 1.3 million for the three months ended 31 October 2015. General and administration expenses increased by 1.8 million to 5.2 million for the nine months ended 31 October 2016 from 3.4 million for the nine months ended 31 October 2015. These increases were primarily due to continuing additional corporate costs associated with being a publicly traded company in the United States as well as in the United Kingdom and an increase in staff related costs offset by a favourable exchange rate variance for both the three months ended 31 October 2016 and nine months ended 31 October 2016. Finance Costs Following an IFRS IC agenda decision in May 2016 on the application of IAS 20 `Government Grants,` the Company has changed its accounting policy regarding charitable funding arrangements from the Wellcome Trust and US Not for Profit organisations. See Note 1 – `Change in accounting policy.` Finance costs relate to the subsequent re-measurement of the financial liability recognised in respect of funding arrangements and the unwinding of the discounts associated with the liabilities. Finance costs decreased by 0.3 million to 0.2 million for the three months ended 31 October 2016 from 0.5 million for the three months ended 31 October 2015 (adjusted). Finance costs decreased by 0.1 million to 0.7 million for the nine months ended 31 October 2016 from 0.8 million for the nine months ended 31 October 2015 (adjusted).

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In Soviet times, the Kremlin ran an extensive operation to subvert the West through what were known as active measures. An estimated 15,000 KGB employees worked, in the words of former KGB General Oleg Kalugin, to drive wedges in the Western community alliances of all sorts, particularly NATO, to sow discord among allies, to weaken the United States in the eyes of the people in Europe, Asia, Africa, Latin America. Putin, as a former KGB officer, is, of course, well aware of this history. Whatever its motivations, paranoia has become Russias foreign policy, with the Kremlin setting up its own fake NGOs and international propaganda-outlets; buying up political actors and supporting extremist groups; enabling hackers, troll farms, rent-a-mobs and corrupt businesspeople to destabilize democracies and eat away at Western alliances. One noticeable aspect of the Kremlins approach is support for European far-right parties which then support the Kremlins foreign policies. The National Front in France, for example, has received funding from Kremlin-connected sources. Another is the use of disinformation to obscure Russian responsibility for such mistakes as bringing down Malaysia Airlines flight MH-17 over Donbass or for bombing a United Nations aid convoy in Syria. Disinformation (dezinformatsiya) was also an important part of Soviet active measures, but the media environment within which it spread has changed. The Soviets tried to prove their fake stories were actually true. Today, the fakes this hyperlink are sprayed into the interview skills course yorkshire chaos of social media and conspiracy websites, adding to the lack of trust in mainstream media and to the overall confusion of so-called post-fact societies. This amounts to not so much an information war, as what some analysts describe as a war on information. At its most effective, the Kremlin does not invent new issues.

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